D. Park

Molecular tension authenticates apoptotic cells being phagocytosed

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

Mx1-labeled pulp progenitor cells are main contributors to postnatal odontoblasts and pulp cells in murine molars

The paper identifies Mx1-labeled pulp progenitor cells as the main contributors to postnatal odontoblasts and pulp cells in murine molars through single-cell analysis and injury studies.

Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor cancer therapy

This study identifies SagA as essential for E. faecium growth, cell separation, and immune checkpoint inhibitor cancer therapy, showing its role in muropeptide production and NOD2 activation.

Reentrant DNA shells tune polyphosphate condensate size

This study investigates how DNA interacts with polyphosphate-Mg2+ condensates, showing DNA forms reentrant shells that regulate condensate size and DNA structure.

Habitat use of loggerhead (Caretta caretta) and green (Chelonia mydas) turtles in the Northwest Pacific Ocean, the northern limit of their distribution range

This study tracks loggerhead and green turtles in the Northwest Pacific to identify foraging areas and highlights seasonal use of the East Sea despite lower temperatures.

Eddy current-induced artifacts correction in high gradient strength diffusion MRI with dynamic field monitoring: demonstration in ex vivo human brain imaging

This paper demonstrates dynamic field monitoring to correct eddy current artifacts in high gradient strength diffusion MRI, showing improved reduction of ghosting and geometric distortions compared to existing methods.

Retrotransposons facilitate tissue-specific horizontal Transfer of circulating tumor DNA

This study shows retrotransposons enable tissue-specific horizontal gene transfer of circulating tumor DNA in cancer cells, influencing treatment response and opening new therapeutic avenues.

A Multifunctional Anchor for Multimodal Expansion Microscopy

This paper introduces a multifunctional anchor for expansion microscopy, enabling simultaneous imaging of multiple biomolecules with reduced cost and complexity.

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

This study shows that loss of DNMT3A causes obesity by disrupting adipogenesis and triggering inflammation in adipose tissue.

Developmental transitions coordinate assembly of the Coxiella burnetii Dot/Icm type IV secretion system

This study uses cryo-ET to show that the Dot/Icm T4SS assembles during the transition from large to small cell variants in Coxiella burnetii.

LRRK2 Phosphorylates Neuronal Elav RNA-Binding Proteins to RegulatePhenotypes Relevant to Parkinson's Disease

This study shows LRRK2 phosphorylates neuronal ELAV proteins, affecting mRNA regulation and contributing to Parkinson's disease pathology in mice.

Modeling the effect of cooperativity in ternary complex formation and targeted protein degradation mediated by heterobifunctional degraders

This paper develops a pharmacodynamic model to study how cooperativity affects ternary complex formation and protein degradation mediated by heterobifunctional degraders.

A Sulfonated Thermoresponsive Injectable Gel for Sequential Release of Therapeutic Proteins to Protect Cardiac Function After a Myocardial Infarction

MRGM: a mouse reference gut microbiome reveals a large functional discrepancy for gut bacteria of the same genus between mice and humans

The paper constructs a mouse reference gut microbiome (MRGM) and finds significant functional discrepancies between mouse and human gut bacteria of the same genus.

Liposomal encapsulation of polysaccharides (LEPS) as an effective vaccine strategy to protect aged hosts against S. pneumoniae infection

This study evaluates a novel LEPS vaccine platform, showing it effectively protects aged mice against pneumococcal infections, with comparable antibody responses and improved function compared to Prevnar-13.

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.

This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

Local protein synthesis of mtIF3 regulates mitochondrial translation for axonal development

This study shows BDNF induces local mtIF3 translation in axons, which supports mitochondrial translation and is necessary for axonal growth.

In situ 3D comparison of Chlorella pyrenoidosa with nuclear-irradiated mutagenic strains by using focused ion beam milling and cryo-electron tomography

This study uses cryo-electron tomography to compare 3D subcellular structures of wild-type and mutagenic Chlorella pyrenoidosa strains, revealing structural changes linked to increased growth rates.

Robust and sensitive detection of SARS-CoV-2 using PCR based methods

This study compares qPCR and ddPCR for SARS-CoV-2 detection, finding ddPCR more sensitive and accurate in quantifying viral RNA from various sources.

Histone Acetyltransferase 1 is Required for DNA Replication Fork Function and Stability

This study shows that Hat1 is essential for DNA replication fork stability and proper histone acetylation during chromatin assembly.

Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2

This study compares the sensitivity of primer-probe sets for detecting SARS-CoV-2 RNA in N and Orf1 genes, identifying the most sensitive sets for each.

Quantification of nosZ genes and transcripts in activated sludge microbiomes with novel group-specific qPCR methods validated with metagenomic analyses

The paper develops and validates group-specific qPCR methods for quantifying nosZ genes and transcripts in activated sludge microbiomes using metagenomic analysis.

Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes

This study quantifies inter-TAD interactions in human cells and shows cohesin depletion reduces both intra- and inter-domain interactions, affecting gene expression near boundaries.

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancer

The paper models how timing of aromatase inhibitor and immune checkpoint inhibitor therapies affects tumor burden and metastatic potential in hormone receptor positive breast cancer.

Visualization of the type III secretion mediated Salmonella-host cell interface using cryo-electron tomography

This study uses cryo-electron tomography to visualize the Salmonella-host cell interface mediated by the type III secretion system, revealing the translocon's structure and its role in effector translocation.

Comparative Analysis of Gene Expression Identifies Distinct Molecular Signatures of Bone Marrow- and Periosteal-Skeletal Stem/Progenitor Cells

The paper compares gene expression between bone marrow and periosteal skeletal stem/progenitor cells to identify molecular differences and markers.

Beyond Autoantibodies: Biological Roles Of Human Autoreactive B Cells In Rheumatoid Arthritis Revealed By Whole Transcriptome Profiling

This study identifies novel roles of autoreactive B cells in RA through transcriptome profiling, revealing potential therapeutic targets and mechanisms.

Rapid Sequential In Situ Multiplexing With DNA-Exchange-Imaging

This paper introduces DNA-Exchange-Imaging, a method for rapid, highly multiplexed in situ protein visualization, achieving sub-20 nm resolution and reducing imaging time from days to minutes.