H. Okano

Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style

The paper shows marmoset infants adjust their attachment behaviors based on caregivers' parenting styles, mirroring human attachment dynamics.

A Metabolic Sum Rule Dictates Bacterial Response to Short-Chain Fatty Acid Stress

The paper identifies a metabolic sum rule in bacteria showing that exogenous metabolite accumulation depletes endogenous metabolites, causing growth reduction, and demonstrates how cells mitigate this by acidifying their cytoplasm.

LRRK2 Phosphorylates Neuronal Elav RNA-Binding Proteins to RegulatePhenotypes Relevant to Parkinson's Disease

This study shows LRRK2 phosphorylates neuronal ELAV proteins, affecting mRNA regulation and contributing to Parkinson's disease pathology in mice.

A Genome-Scale Metabolic Model of Marine Heterotroph Vibrio splendidus sp. 1A01

The paper constructs a genome-scale metabolic model for Vibrio splendidus sp. 1A01 to study its metabolism and addresses challenges in modeling marine microorganisms.

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

This study develops a bulk differentiation method for MYOD1-hiPSCs to generate contractile skeletal muscles, improving efficiency and reducing clonal variation compared to clonal methods.

A role of cryptochrome for magnetic field-dependent improvement of sleep quality, lifespan and motor function in Drosophila

The paper shows that AC magnetic field exposure improves sleep, lifespan, and motor function in Drosophila, but not in cryptochrome mutants, suggesting a cry-dependent pathway.

Localization of planteose hydrolysis during seed germination of Orobanche minor

This study identifies planteose as a storage carbohydrate in Orobanche minor seeds and shows its hydrolysis by OmAGAL2 in the apoplast during germination, suggesting it as a target for weed control.

Comparative analyses of gene expression in common marmoset and human pluripotent stem cells (PSCs) identify factors enhancing homologous recombination efficiency in the HPRT locus of human PSCs

Effects of a 50-Hz electric field on sleep quality and life span mediated by ultraviolet (UV)-A/blue light photoreceptor CRYPTOCHROME in Drosophila melanogaster

The paper shows that a 50-Hz electric field improves sleep and extends lifespan in Drosophila, effects mediated by the CRYPTOCHROME gene.

Senescent cell death as an aging resistance mechanism in naked mole-rat

This study identifies senescent cell death as a mechanism contributing to the aging resistance in naked mole-rats, linking low antioxidant defense with suppressed senescent cell accumulation.

Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a poikilothermic mammal

This study investigates brown adipose tissue thermogenesis in naked mole-rats, showing ADRB3-dependent thermogenic activity and its role in thermoregulation in non-cold environments.

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenarians

This study identifies an increase in cytotoxic CD4 T-cells and a reduction in B-cells in supercentenarians through single-cell transcriptomics.