Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity
E. H. Garst, H. Lee, T. Das, S. Bhattacharya, A. Percher, R. Wiewiora, I. P. Witte, Y. Li, M. Goger, T. Peng, W. Im, H. C. Hang
This study shows site-specific S-palmitoylation of IFITM3 enhances its membrane interactions and antiviral activity by modulating its conformation and lipid membrane binding.
bioRxiv · Sep 11, 2020Biochemistry