T. Peng

Hallmarks of tumor-experienced T cells are absent in multiple myeloma patients from diagnosis through maintenance therapy

The paper profiles CD8+ T cells in multiple myeloma patients to assess tumor reactivity and exhaustion, finding no evidence of tumor-experienced T cells with hallmark exhaustion or activation features.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

The paper investigates the role of IL-5+ lymphocytes and type 3/17 lymphocytes in liver fibrosis, showing their spatial relationship and cross-regulation in fibroblast niches.

CellDeathPred: A Deep Learning framework for Ferroptosis and Apoptosis prediction based on cell painting

CellDeathPred uses deep learning on cell painting images to predict ferroptosis and apoptosis with 95% accuracy in human cells.

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

Gli2 and Gli3 Regulate Horizontal Basal Cell-Mediated Regeneration of the Olfactory Epithelium

This study shows GLI2 and GLI3 regulate HBC-mediated olfactory epithelium regeneration by controlling proliferation, identity, and differentiation of HBCs following injury.

Early Life Exposure to Queen Mandibular Pheromone Mediates Persistent Transcriptional Changes in the Brain of Honey bee Foragers

This study shows that early exposure to queen mandibular pheromone in honey bees leads to long-term transcriptional changes in brain and sensory tissues, affecting division of labor, learning, and aging, but not foraging activity.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

Use of waggle dance information in honey bees is linked to gene expression in the antennae, but not in the brain

The study finds that gene expression in honey bee antennae, not the brain, is linked to the use of social information from waggle dances, with differences in dopamine and odor perception genes.

Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

This study shows site-specific S-palmitoylation of IFITM3 enhances its membrane interactions and antiviral activity by modulating its conformation and lipid membrane binding.

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

The paper identifies p16INK4a+ mesenchymal cells in the lung basement membrane as reparative sentinels that transition to a senescence-associated secretory phenotype to support epithelial repair.

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair

This study shows human alveolar type 2 cells can transdifferentiate into KRT5+ basal cells in 3D organoids, a process linked to IPF pathology and not observed in murine cells.

2'3'-cGAMP triggers a STING and NF-κB dependent broad antiviral response in Drosophila

This study shows that 2'3'-cGAMP activates dSTING and NF-κB to trigger a broad antiviral response in Drosophila, independent of autophagy and RNAi pathways.

Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis

This study shows Gli1+ mesenchymal stromal cells drive metaplastic differentiation of airway progenitors into KRT5+ basal cells in fibrosis by modulating BMP activation through hedgehog signaling.

Multi-task learning of a deep k-nearest neighbour network for histopathological image classification and retrieval

This paper introduces a multi-task deep learning framework for histopathological image classification and retrieval using k-nearest neighbors to improve interpretability.