Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.
E. Coppin, B. S. Sundarasetty, S. Rahmig, J. Blume, N. A. Verheyden, F. Bahlmann, S. Ravens, U. Schubert, J. Schmid, S. Ludwig, C. von Kaisenberg, A. Platz, R. Naumann, B. Ludwig, I. Prinz, , A. Krueger
This study creates a humanized mouse model with enhanced T cell differentiation by expressing human IL-7 in specific tissues, leading to increased functional T cells without lymphoproliferation.
bioRxiv · Apr 24, 2020Immunology