Author

A. Polasa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 6 Approach:statistical model· 3 Assay:structural biology· 3 Approach:biophysical modeling· 2 Approach:mechanistic / dynamical model· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Moradi· 7 shared J. Losey· 3 shared K. Immadisetty· 2 shared A. Abbaspourrad· 1 shared A. Cortes-Cubero· 1 shared D. S. Matteson· 1 shared D. S. Ogden· 1 shared H. Wu· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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7 shared papersBiophysics

M. Moradi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Differential Behavior of Conformational Dynamics in Active and Inactive States of Cannabinoid Receptor 1

U. H. Isu, A. Polasa, M. Moradi

This study uses molecular dynamics simulations to compare conformational dynamics of inactive and active states of CB1 receptor, identifying key structural differences and electrostatic interactions that influence its function.

The Journal of Physical Chemistry B · Aug 22, 2024Peer-reviewedBiophysics

Deciphering the Inter-domain Decoupling in the Gram-negative Bacterial Membrane Insertase

A. Polasa, S. A. Badiee, M. Moradi

This study uses molecular dynamics simulations to investigate the structure and function of YidC in gram-negative bacteria, revealing its role in protein insertion and highlighting domain interactions.

bioRxiv · Aug 9, 2022 · PreprintBiophysics

An Investigation of the YidC-Mediated Membrane Insertion of Pf3 Coat Protein Using Molecular Dynamics Simulations

A. Polasa, J. Hettige, K. Immadisetty, M. Moradi

This study uses molecular dynamics simulations to investigate the YidC-mediated insertion of Pf3 coat protein, revealing the role of YidC's hydrophilic groove in protein transport.

bioRxiv · May 28, 2022 · PreprintBiophysics

Computational Elucidation of Recombinant Fusion Protein Effect on Peptide-Directed Nanoparticles

A. Polasa, I. Mosleh, J. Losey, A. Abbaspourrad, R. Beitle, M. Moradi

This study uses molecular dynamics simulations to analyze how peptide sequences and their binding to GFPuv affect nanoparticle properties and free energies.

bioRxiv · Mar 11, 2021 · PreprintBioengineering

Elucidating the Molecular Basis of pH Activation of an Engineered Mechanosensitive Channel

K. Immadisetty, A. Polasa, R. Shelton, M. Moradi

This paper uses molecular dynamics simulations to elucidate the atomic-level activation mechanism of an engineered MscL channel triggered by pH changes, identifying key structural changes and interactions involved.

bioRxiv · Mar 11, 2021 · PreprintBiophysics

Simulating freely-diffusing single-molecule FRET data with consideration of protein conformational dynamics

J. Losey, M. Jauch, A. Cortes-Cubero, H. Wu, A. Polasa, S. Sauve, R. Rivera, D. S. Matteson, M. Moradi

The paper simulates freely-diffusing single-molecule FRET data with conformational dynamics using Langevin dynamics to test analysis techniques for flexible proteins.

bioRxiv · Jan 19, 2021 · PreprintBiophysics

Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2

V. Govind Kumar, D. S. Ogden, U. Isu, A. Polasa, J. Losey, M. Moradi

This study uses molecular dynamics simulations to compare the dynamic behavior of prefusion spike proteins in SARS-CoV-1 and SARS-CoV-2, finding that SARS-CoV-2's spike is more stable with a higher energy barrier for activation.

bioRxiv · Dec 25, 2020 · PreprintBiophysics