BiochemistrybioRxivPreprint
Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP
M. D. Callahan, M. Hodul, E. C. Carroll…·J. E. Gestwicki
This study identifies CHIC2 as a chaperone-independent regulator of CHIP, showing it attenuates CHIP's ubiquitin ligase activity and contributes to neurodegeneration in C. elegans.
DOI 10.1101/2023.07.17.549407