SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
S. Maharana, S. Kretschmer, S. Hunger, X. Yan, D. Kuster, S. Traikov, T. Zillinger, N. Chappidi, N. Lucas, K. I. Maser, H. Maatz, A. Rapp, V. Marchand, V. Iyer, A. Chhabra, , M. A. Lee-Kirsch
This study shows SAMHD1 regulates innate immunity by controlling RNA condensation, preventing immune recognition of self RNA and reducing inflammation.
bioRxiv · Jul 12, 2022Immunology