X. Yan

Moderate-term dimethyl fumarate treatment reduces pathology of dystrophic skeletal and cardiac muscle in a mouse model

This study shows that moderate-term dimethyl fumarate treatment reduces dystrophic muscle pathology in a mouse model of Duchenne muscular dystrophy, with anti-inflammatory, anti-fibrotic, and anti-lipogenic effects.

Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of Alpha-Synuclein and Restores Impaired Mitochondrial Function

This study shows SS-31 reduces alpha-synuclein membrane binding, aggregation, and mitochondrial dysfunction in neuroblastoma cells.

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

Identifying Intermolecular Interactions in Single-Molecule Localization Microscopy

This paper develops a probabilistic algorithm to accurately identify and quantify intermolecular interactions using single-molecule localization microscopy.

Identification of Candidate Diagnostic gene CDC25C for Trametinib-induced Cardiotoxicity by Integrating Bioinformatics and Machine Learning

Aggresomes protect mRNA under stress in Escherichia coli

The paper shows that aggresomes in E. coli store mRNA under stress, aiding rapid recovery by protecting mRNA from degradation and facilitating translation reactivation.

Bayesian parameter inference for epithelial mechanics

This study improves parameter estimation in epithelial mechanics models using Bayesian statistics, showing accurate results on synthetic data and revealing the dispensability of cortical elasticity in vivo.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Antimicrobial resistance, virulence genes profiles and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae strains from captive giant pandas (Ailuropoda melanoleuca)

This study analyzed antibiotic resistance, virulence genes, and molecular epidemiology of CRKP strains from giant pandas, revealing diverse genetic profiles and high genetic diversity.

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity.

This study identifies Pwl2 as a virulence factor in the rice blast fungus that suppresses host immunity by altering the localization of HIPP43.

Distinct Roles of Kif6 and Kif9 in Mammalian Ciliary Trafficking and Motility

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.

Time-dependent Interaction Modification Generated from Plant-soil Feedback

The paper shows that time-dependent interaction modifications in plant-soil feedback depend on germination phenology and microbiome overlap, affecting plant coexistence.

Zinc-finger (ZiF) fold secreted effectors form a functionally diverse family across lineages of the blast fungus Magnaporthe oryzae.

The paper identifies a functionally diverse family of Zinc-finger fold effectors in Magnaporthe oryzae, showing functional specialization across host species.

Duplication and neofunctionalization of a horizontally-transferred xyloglucanase as a facet of the red queen co-evolutionary dynamic

The paper investigates the duplication and neofunctionalization of a horizontally-transferred xyloglucanase gene in oomycetes, showing how these variants contribute to plant pathogenesis and host-pathogen co-evolution.

Genomic analysis of Coccomyxa viridis, a common low-abundance alga associated with lichen symbioses

The paper presents the first genome sequence of Coccomyxa viridis, a non-photobiont lichen-associated alga, revealing traits linked to its lichen lifestyle and providing insights into the evolution of lichen symbiosis.

A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

The phosphorylation landscape of infection-related development by the rice blast fungus

This study maps the phosphorylation landscape of the rice blast fungus during infection, identifying key phosphoproteins and pathways involved in disease progression.

Detection and characterization of a novel bat filovirus (Dehong virus, DEHV) in fruit bats

The paper detects and characterizes a novel bat filovirus, Dehong virus (DEHV), from Rousettus leschenaultii bats, placing it phylogenetically between Dianlovirus and Marburgvirus.

Chemoproteomics reveals the epoxidase enzyme for the biosynthesis of camptothecin precursor strictosamide epoxide

This study identifies the epoxidase enzyme responsible for converting strictosamide to its epoxide form using a chemoproteomic approach in Ophiorrhiza pumila.

Histone variant H2A.Z is required for plant salt response by regulating gene transcription

This study shows H2A.Z regulates plant salt response by modulating gene transcription, with its occupancy affecting gene expression levels under salt stress.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques

This study introduces an Fcγ-receptor independent agonistic anti-CD40 antibody that activates immune cells in vitro and in vivo in rhesus macaques, showing potential as an immunostimulatory adjuvant.

CryoFIB milling large tissue samples for cryo-electron tomography

This paper introduces a cryoFIB milling workflow for isolating objects of interest from large tissue samples, resulting in thin lamellae suitable for cryo-electron tomography.

Study on the mechanism of HE4 in hyperoxia-induced alveolar damage in rats

This study examines how HE4 contributes to hyperoxia-induced alveolar damage in rats by activating ERK and p65, modulating MMP9 and TIMP1 pathways, and promoting fibrosis.

Intrinsically disordered proteins SAID1/2 condensate on SERRATE/ARS2 for dual inhibition of miRNA biogenesis in Arabidopsis

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.

Why is Babesia not killed by artemisinin like Plasmodium?

This study compares Babesia and Plasmodium genomes and gene expression to explain why Babesia is not killed by artemisinin, finding differences in haem synthesis, iron utilization, and gene expression.

The transcriptional landscape of plant infection by the rice blast fungus Magnaporthe oryzae reveals distinct families of temporally co-regulated and structurally conserved effectors