D. Kuster

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

This study shows SAMHD1 regulates innate immunity by controlling RNA condensation, preventing immune recognition of self RNA and reducing inflammation.

TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana

The paper shows that TOR kinase regulates auxin-dependent lateral root initiation in Arabidopsis by modulating translation of key auxin targets and integrating metabolic signals.

High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform

This paper introduces a microdroplet platform to rapidly generate high-resolution phase diagrams of biomolecular condensates and demonstrates its application in studying phase transitions.

Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast

The paper identifies NAD-RNAs in yeast, showing they are abundant, short, and guarded by decapping enzymes, with in vitro evidence of translational rejection.

Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

The paper shows mitochondrial RNA polymerases in yeast and human cells efficiently cap RNA with NAD+ and NADH, linking metabolism to mitochondrial gene expression.