A structural competition involving WDR5 times circadian oscillations
A. Boergel, A. Rawleigh, M. Conrady, F. Hof, K. Ricci, S. Brown, E. Wolf
This study identifies WDR5 as a direct interaction partner of PER1 and PER2, showing its role in modulating circadian oscillations through structural competition at the BMAL1/CLOCK interface.
bioRxiv · Jun 5, 2023 · PreprintBiochemistry