S. Brown

Clostridioides difficile Toxins Alter Host Metabolic Pathway and Bile Acid Homeostasis Gene Expression In Colonic Epithelium

This study shows that C. difficile toxins alter host gene expression related to metabolic pathways and bile acid homeostasis in colonic epithelial cells.

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Participatory science methods to monitor water quality and ground truth remote sensing of the Chesapeake Bay

The paper describes participatory science methods for monitoring water quality in the Chesapeake Bay using volunteer scientists and remote sensing to improve data collection and algorithm development.

CoralBleachRisk- Global projections of coral bleaching risk in the 21st century

The paper introduces a global dataset and tool to project coral bleaching risk from 1985 to 2100 under different climate scenarios.

Cancer-Associated Hypercalcemia Signals Through the Hindbrain to cause Anorexia

This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.

Anti-Immune Complex Antibodies are Elicited During Repeated Immunization with HIV Env Immunogens

The paper identifies anti-immune complex antibodies generated through repeated HIV Env immunizations and presents their structures using polyclonal epitope mapping.

Impact of genomic background and developmental state on signaling pathways and response to therapy in Glioblastoma patient-derived cells

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

The collective application of shorebird tracking data to conservation

The paper describes a collaborative effort to integrate shorebird tracking data for conservation, showing how shared data can support conservation actions.

Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

The paper uses a novel computational workflow to analyze a spatiotemporally profiled GBM xenograft cohort, identifying 15 tumor cell programs related to invasion and their prognostic significance in GBM patients.

Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain

The paper describes the use of TELSAM fusion crystallization to determine the structure of the TNK1 UBA domain and its interaction with polyubiquitin.

A structural competition involving WDR5 times circadian oscillations

This study identifies WDR5 as a direct interaction partner of PER1 and PER2, showing its role in modulating circadian oscillations through structural competition at the BMAL1/CLOCK interface.

Rickettsia parkeri Hijacks Tick Hemocytes to Manipulate Cellular and Humoral Transcriptional Responses

This study identifies five hemocyte populations in ticks and shows Rickettsia parkeri infects phagocytic hemocytes, altering immune gene expression and phagocytosis.

GAME BIRD CARCASSES ARE LESS PERSISTENT THAN RAPTOR CARCASSES, BUT CAN PREDICT RAPTOR PERSISTENCE DYNAMICS

The paper compares carcass persistence of raptors and game birds at wind energy facilities and develops a model to predict raptor persistence using game bird data.

Incidental Eagle Carcass Detection Can Contribute to Fatality Estimation at Operating Wind Facilities

This study quantifies how wind facility O&M staff can incidentally detect eagle carcasses, finding detection probabilities range from 0.07 to 0.47.

Precision Discovery of Novel Inhibitors of Human Cancer Target HsMetAP1 from Vast Unexplored Metagenomic Diversity

The paper discovers novel inhibitors of HsMetAP1 from metagenomic data using computational and synthetic biology methods.

Chemically modified dsRNA induces RNAi effects in insects in vitro and in vivo: A potential new tool for improving RNA-based plant protection

This study shows chemically modified long dsRNA improves RNAi efficacy in insects, leading to mortality in both cell cultures and live insects.

Three-dimensional in vitro model of the device-tissue interface reveals innate neuroinflammation can be mitigated by antioxidant ceria nanoparticles

This study develops a 3D in vitro model of the device-tissue interface to show that antioxidant ceria nanoparticles reduce oxidative stress and neuroinflammation.

Selfish bacteria are active throughout the water column of the ocean

The paper shows that selfish bacteria are active in deep ocean waters, suggesting that the return on investment for their energy-intensive strategy is sufficient to sustain them in these environments.

TELSAM polymers accelerate crystallization of fused target proteins by stabilizing minimal crystal contacts and in the absence of direct inter-TELSAM contacts

This study shows that TELSAM polymers enhance protein crystallization by stabilizing minimal crystal contacts and enabling rapid crystallization without direct inter-TELSAM contacts.

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

This study shows that TGFβ signalling maintains naive human pluripotency by regulating SMAD2/3 binding and gene expression, with distinct effects compared to primed hPSCs.

Exploring correlations in cultural and genetic variation across language families in Northeast Asia

The paper analyzes correlations between cultural and genetic variation across 11 language families in Northeast Asia, finding grammatical structure correlates with population history.

Epigenetic regulations follow cell cycle progression during differentiation of human pluripotent stem cells.

This study investigates epigenetic changes during the first two cell divisions of human pluripotent stem cell differentiation using synchronized cultures and identifies key regulatory mechanisms.

Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells

The paper shows that transcriptional networks and chromatin dynamics change during the cell cycle in human embryonic stem cells.

Observations on the interactions of mammals and birds with badger (Meles meles) dung pits at a site used by a single social group in an urban area

The paper observes mammalian and avian interactions with badger dung pits using infrared cameras, finding 28% of behaviors involve material harvesting.

Hygiene Hampers Competitive Release Of Resistant Bacteria In The Commensal Microbiota

This study uses metacommunity ecology theory to show that hygiene reduces the competitive release of resistant bacteria by modulating strain distribution in host populations, thereby weakening the link between antibiotic use and resistance.

Population genome sequencing of the scab fungal species Venturia inaequalis, Venturia pirina, Venturia aucupariae and Venturia asperata.

The paper reports whole genome sequencing of Venturia fungal species to understand their genetic structure and genomic features, revealing high transposable element content and clone relationships.

Parkinsons disease and bacteriophages as its overlooked contributors

The paper analyzes bacteriophage composition in PD patients and healthy individuals, finding altered phage/bacteria ratios and depletion of Lactococcus spp. linked to PD pathogenesis.

Haemolymph removal by the parasite Varroa destructor can trigger the proliferation of the Deformed Wing Virus in mite infested bees (Apis mellifera), contributing to enhanced pathogen virulence

The paper shows that removing haemolymph from bees by Varroa destructor mites increases Deformed Wing Virus density, suggesting mite feeding disrupts viral immune control.

A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability

This study identifies MASK as a positive regulator of cytokine receptor stability through a genome-wide RNAi screen in Drosophila and validates its function in human cells.