Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant
L. G. Thorne, M. Bouhaddou, A.-K. Reuschl, L. Zuliani-Alvarez, B. J. Polacco, A. Pelin, J. Batra, M. V. X. Whelan, M. Ummadi, A. Roic, J. Turner, K. Obernier, H. Braberg, M. Soucheray, A. L. Richards, , N. J. Krogan
This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.
bioRxiv · Jun 6, 2021 · PreprintMicrobiology