Author

M. Soucheray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

N. J. Krogan· 5 shared A. Garcia-Sastre· 3 shared D. L. Swaney· 3 shared A.-K. Reuschl· 2 shared B. J. Polacco· 2 shared C. Jolly· 2 shared D. Swaney· 2 shared G. J. Towers· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMicrobiology

N. J. Krogan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

T. Kehrer, A. Cupic, C. Ye, S. Yildiz, M. Bouhhadou, N. A. Crossland, E. Barrall, P. Cohen, A. Tseng, T. Cagatay, R. Rathnasinghe, D. Flores, S. Jangra, F. Alam, N. Mena, , L. Miorin

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

bioRxiv · Oct 18, 2022Microbiology

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

L. G. Thorne, M. Bouhaddou, A.-K. Reuschl, L. Zuliani-Alvarez, B. J. Polacco, A. Pelin, J. Batra, M. V. X. Whelan, M. Ummadi, A. Roic, J. Turner, K. Obernier, H. Braberg, M. Soucheray, A. L. Richards, , N. J. Krogan

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

A.-K. Reuschl, L. Thorne, L. Zuliani Alvarez, M. Bouhaddou, K. Obernier, J. Hiatt, M. Soucheray, J. Turner, J. Fabius, G. T. Nguyen, D. Swaney, R. Rosales, K. M. White, P. Aviles, I. T. Kirby, , N. J. Krogan

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

bioRxiv · Jan 24, 2021 · PreprintMicrobiology

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

P. Finneran, M. Soucheray, C. Wilson, R. Otten, V. Buosi, N. J. Krogan, D. Swaney, D. Theobald, D. Kern

This study reveals the bimodal evolution of Src and Abl kinase substrate specificity using mammalian cell extract as a substrate pool, showing divergent evolutionary paths leading to specific and promiscuous enzymes.

bioRxiv · Aug 12, 2020 · PreprintBiochemistry

Brown adipocyte NOSEMPE promotes nonmitochondrial thermogenesis and improves systemic metabolism through ATF4 activation

E. Paulo, Y. Zhang, R. Masand, T. L. Huynh, Y. Seo, D. L. Swaney, M. Soucheray, D. Jimenez-Morales, N. J. Krogan, B. Wang

The paper identifies NOSEMPE in brown adipocytes as a cause of mitochondrial ETC imbalance and shows it drives nonmitochondrial thermogenesis and metabolic improvement via ATF4 activation.

bioRxiv · Apr 16, 2019 · PreprintPhysiology