J. Turner

Cellular heterogeneity in hypertrophic burn scars in response to carbon dioxide laser therapy

This study uses single-cell RNA sequencing to analyze how hypertrophic burn scars respond to carbon dioxide laser therapy, identifying gene expression patterns and cell types associated with good or poor outcomes.

In vivo tracking of ex vivo generated 89Zr-oxine labeled plasma cells by PET in a non-human primate model

The paper demonstrates a method to track ex vivo generated B cells in non-human primates using PET imaging, showing stable distribution and feasibility of repeated infusions.

Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic E. coli adhesin

This study identifies key structural and glycosylation features of EtpA, an ETEC adhesin, and shows how antibodies target different epitopes to influence immune responses and pathogen-host interactions.

Impact of the elderly lung mucosa on Mycobacterium tuberculosis metabolic adaptation during infection of alveolar epithelial cells

This study shows that elderly lung mucosa alters Mycobacterium tuberculosis gene expression, enhancing its metabolic adaptation and survival in alveolar epithelial cells.

Mitochondrial Transplantation promotes protective effector and memory CD4+ T cell response during Mycobacterium tuberculosis infection and diminishes exhaustion and senescence in elderly CD4+ T cells

This study shows mitochondrial transplantation enhances CD4+ T cell function in elderly individuals and mice infected with Mycobacterium tuberculosis by reducing exhaustion and senescence.

Drivers of Bird Communities in an Urban Neighborhood Vary by Scale

This study examines how bird community metrics relate to vegetation and air pollution at multiple spatial scales in an urban neighborhood, finding positive associations with greenness and negative associations with air pollution.

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease

This study shows that deleting Lgr4/5 in mouse livers disrupts Wnt/β-catenin signaling, leading to fatty liver disease and fibrosis.

A Novel Model of Estrogen Receptor-Positive Breast Cancer Bone Metastasis with Antiestrogen Responsiveness

This paper develops an immunocompetent ER+ breast cancer mouse model with spontaneous bone metastasis and antiestrogen responsiveness, showing treatment efficacy with tamoxifen and fulvestrant.

IL-10 receptor blockade delivered simultaneous with BCG vaccination sustains long term protection against Mycobacterium tuberculosis infection in mice

This study shows that combining BCG vaccination with IL-10 receptor blockade in mice provides long-term protection against M.tb infection, improving T cell responses and survival.

Assembled Cell-Decorated Collagen (AC-DC) bioprinted implants mimic musculoskeletal tissue properties and promote functional recovery

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis growth in alveolar epithelial cells and bacterial translocation into the cytosol

Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4+ T Cells in Aging.

This study transfers functional mitochondria into aged CD4+ T cells, improving their metabolism, reducing oxidative stress, and enhancing immune function against infections.

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

Acute inflammation, mediated by lung neutrophils, confers enhanced protection against Mycobacterium tuberculosis infection in mice

This study shows that acute inflammation induced by LPS in mice enhances protection against M.tb infection by increasing neutrophil activity and reducing bacterial burden.

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

Blood RNA Signatures Predict Recent Tuberculosis Exposure in Mice, Macaques and Humans

The paper identifies a blood RNA signature that detects recent M.tb exposure in mice, macaques, and humans, with a 6-gene signature showing promise in human cohorts.

Micro-scale fluid behavior during cryo-EM sample blotting

This paper investigates micro-scale fluid dynamics during cryo-EM sample blotting and identifies issues with uniformity in ice thickness resulting from filter paper interactions.

Pathologically distinct fibroblast subsets drive inflammation and tissue damage in arthritis

The paper identifies two distinct fibroblast subsets in arthritis that drive inflammation or tissue damage, showing their unique roles in disease progression.