Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, 4-repeat/full-length tau and alpha-synuclein
J. Sobek, J. Li, B. F. Combes, J. A. Gerez, P. K. Nilsson, M. T. Henrich, F. F. Geibl, K. Shi, A. Rominger, W. H. Oertel, R. M. Nitsch, A. Nordberg, H. Agren, R. Riek, R. Ni
The paper develops an SPR-based method to characterize small molecule ligands binding to amyloid-beta, tau, and alpha-synuclein fibrils, identifying multiple binding sites.
bioRxiv · Mar 12, 2023 · PreprintPharmacology & Toxicology