The paper identifies three sequential W-autosome fusions in Heliconius butterflies, revealing their role in adaptive radiation and sex chromosome evolution.

bioRxiv · Mar 6, 2023 · PreprintEvolutionary Biology

Multiple paths towards repeated phenotypic evolution in the spiny-leg adaptive radiation (Tetragnatha; Hawaii)

J. Cerca, D. D. Cotoras, C. G. Santander, V. C. Bieker, L. Hutchins, J. Morin-Lagos, C. F. Prada, S. Kennedy, H. Krehenwinkel, A. Rominger, J. Meier, D. Dimitrov, T. Struck, R. G. Gillespie

This study investigates the genomic basis of repeated ecomorph evolution in Hawaiian spiny-leg Tetragnatha, finding multiple genetic pathways and roles for learning and circadian rhythms.

bioRxiv · Nov 29, 2022Evolutionary Biology

Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

T. Hongu, M. Pein, J. Insua-Rodriguez, J. Meier, K. Decker, A. Descot, A. Riedel, T. Oskarsson

The paper identifies four secreted factors from metastasis-associated endothelial cells that promote breast cancer metastasis by enhancing cancer cell stemness and survival, with perivascular macrophages mediating this effect via the TNC-TLR4 axis.

bioRxiv · Mar 30, 2021Cancer Biology

Glycine receptor α3K governs mobility and conductance of L/K splice variant heteropentamers

V. Lemmens, B. Thevelein, S. Kankowski, H. Mizuno, J. Meier, S. Rocha, B. Brone, J. Hendrix

This study functionally characterizes GlyR-3 splice variant heteropentamerization using fluorescence microscopy and electrophysiology, showing they adopt the mobility of the K variant and exhibit conductance similar to 3K.

bioRxiv · Feb 18, 2021Biochemistry

Altitude and life-history shape the evolution of Heliconius wings

G. Montejo-Kovacevich, J. E. Smith, J. Meier, C. N. Bacquet, E. Whiltshire-Romero, N. J. Nadeau, C. Jiggins

This study examines how altitude and life-history traits influence wing shape and size divergence in Heliconius butterflies, revealing novel adaptive morphological patterns beyond coloration.

bioRxiv · Jul 2, 2019Evolutionary Biology

CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization

M. Pein, J. Insua-Rodriguez, J. Meier, T. Hongu, L. Wiedmann, M. A. G. Essers, H.-P. Sinn, S. Spaich, M. Sutterlin, A. Schneeweiss, A. Trumpp, T. Oskarsson

This study identifies CXCR3-expressing breast cancer cells that induce fibroblast production of CXCL9/10 via IL-1 and JNK signaling, promoting metastatic colonization in the lungs.

bioRxiv · Feb 11, 2019Cancer Biology

T Cell Repertoire Evolution After Allogeneic Bone Marrow Transplantation: An Organizational Perspective

J. Meier, M. Fawaz, H. Abdeen, J. Reed, C. Kanakry, L. Luznik, A. Toor

This study quantifies T cell repertoire reconstitution after bone marrow transplantation by analyzing TCR β sequence organization, finding reduced repertoire complexity post-transplant and preserved VJ segment symmetry.

bioRxiv · May 21, 2018Immunology

Hybridization, sex specific genomic architecture and local adaptation

A. Runemark, F. Eroukhmanoff, A. N. Bolanos, J. S. Hermansen, J. Meier

The paper examines how hybridization affects sexual dimorphism, conflict, and local adaptation through sex-specific genomic mechanisms.

bioRxiv · Apr 6, 2018Evolutionary Biology