S. Kennedy

Germ granule compartments coordinate specialized small RNA production

The paper identifies a new subcompartment in C. elegans germ granules that facilitates specialized small RNA production, essential for fertility and RNAi response.

Facilitating taxonomy and phylogenetics: An informative and cost-effective protocol integrating long amplicon PCRs and third-generation sequencing

This paper introduces a cost-effective PCR-based protocol for generating long amplicons of mitochondrial and nuclear genes in spiders, enabling accurate phylogenetic inference with low infrastructure requirements.

The Colibactin-Producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance.

This study shows that Colibactin-producing Escherichia coli creates an immunosuppressive lipid-rich tumor microenvironment that promotes colorectal cancer progression and chemoresistance.

Multiple paths towards repeated phenotypic evolution in the spiny-leg adaptive radiation (Tetragnatha; Hawaii)

This study investigates the genomic basis of repeated ecomorph evolution in Hawaiian spiny-leg Tetragnatha, finding multiple genetic pathways and roles for learning and circadian rhythms.

Optimizing bioink composition for human chondrocyte expression of lubricin

This study identifies an optimal bioink composition for enhancing lubricin expression in human chondrocytes using a high-throughput reporter system and 3D bioprinting.

Correction of age-associated defects in dendritic cell functions enables CD4+ T cells to eradicate tumors in the elderly

This study shows that CD4+ T cells, supported by hyperactivator-stimulated dendritic cells, can eliminate tumors in elderly mice, suggesting a strategy to correct age-related immune defects.

Phenogenomic characterization of a newly domesticated and novel species from the genus Verrucosispora

This study domesticates a novel marine Actinomycetes species, revealing genomic changes linked to growth, metabolism, and antibiotic potential during cultivation.

The Eruca sativa genome and transcriptome: A targeted analysis of sulfur metabolism and glucosinolate biosynthesis pre and postharvest

The paper presents the first de novo genome and transcriptome analysis of Eruca sativa, identifying gene expression patterns related to sulfur metabolism and glucosinolate biosynthesis pre and postharvest.

Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain

The paper identifies small molecule fragments that bind to the tudor domain of SETDB1 and describes their binding modes and biophysical properties.

1,4-dihydroxy Quininib Attenuates Growth of Colorectal Cancer Cells and Xenografts and Regulates the TIE-2 Signaling Pathway in Patient Tumours

This study shows that Q8, a modified quininib, inhibits colorectal cancer growth and angiogenesis by targeting the TIE-2 signaling pathway in both cell and xenograft models.

Chromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans

The paper shows that small RNAs and the nuclear RNAi machinery drive chromatin compaction in C. elegans germ cells via NRDE-3, NRDE-2, and HPL-2.

A Multiplexed DNA FISH strategy for Assessing Genome Architecture in C. elegans

This paper introduces a multiplexed DNA FISH method for visualizing genome architecture in C. elegans at multiple scales across developmental stages.

A compendium of co-regulated protein complexes in breast cancer reveals collateral loss events

The paper identifies 258 protein complexes in breast cancer and finds that mutations in one subunit often lead to reduced expression of other complex members, a phenomenon observed in proteomic but not transcriptomic data.

In-Depth Resistome Analysis by Targeted Metagenomics

The paper introduces ResCap, a targeted metagenomics platform for analyzing resistomes, enhancing sensitivity and specificity in detecting antimicrobial resistance genes.