Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals
E. Labaronne, D. Decimo, L. Bertrand, L. Guiguettaz, T. J. Sohier, D. Cluet, V. Vivet-Boubou, C. Dahoui, P. Francois, I. Hatin, O. Lambotte, A. Samri, B. Autran, L. Etienne, C. Goujon, , E. Ricci
The paper characterizes HIV-1 translational landscape, revealing uORF translation and its role in DDX3 dependency and T cell immune responses.
bioRxiv · Apr 29, 2022Microbiology