Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels
I. Budde, A. Schlichting, D. Ing, S. Schimmelpfennig, A. Kuntze, B. Fels, J. M.-J. Romac, S. M. Swain, R. A. Liddle, A. Stevens, A. Schwab, Z. Petho
This study identifies Piezo1, TRPC1, and TRPV4 as mechanosensitive ion channels crucial for durotaxis in pancreatic stellate cells, which contributes to pancreatic cancer progression.
bioRxiv · Dec 22, 2023Physiology