A. Senoo

Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA.

This study uses lipid nanodiscs and surface plasmon resonance to identify a fragment compound that inhibits MsbA's ATPase activity, suggesting a pathway for developing stronger inhibitors.

Structural basis for binding mechanism of human serum albumin complexed with cyclic peptide dalbavancin

This study determines the crystal structure of human serum albumin bound to dalbavancin, revealing the binding mechanism and structural changes involved.

On-rate modulation of cadherin interactions by chemical fragments

This study identifies a chemical fragment that modulates the on-rate of P-cadherin dimerization by inhibiting cell adhesion.