Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA.
K. Fujimoto, A. Senoo, S. Nagatoishi, T. Ueda, K. Tsumoto, J. Caaveiro
This study uses lipid nanodiscs and surface plasmon resonance to identify a fragment compound that inhibits MsbA's ATPase activity, suggesting a pathway for developing stronger inhibitors.
bioRxiv · Jun 15, 2021 · PreprintBiophysics