Sub-lethal radiation-induced senescence impairs resolution programs and drives cardiovascular inflammation
S. Sadhu, C. Decker, B. E. Sansbury, M. Marinello, A. Seyfried, J. Howard, M. Mori, Z. Hosseini, T. Arunachalam, A. V. Finn, J. M. Lamar, D. Jourd'heuil, L. Guo, K. C. MacNamara, M. Spite, G. Fredman
This study shows sub-lethal radiation induces macrophage senescence, impairing efferocytosis and promoting cardiovascular inflammation, with RvD1 treatment reversing these effects.
bioRxiv · May 19, 2021Immunology