L. Guo

Structural insights into the in situ assembly of clustered protocadherin γB4

This study investigates the in situ assembly of cPcdh-γB4 using electron tomography, revealing distinct roles of ectodomain and intracellular domain in intermembrane organization.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

PerturBase: a comprehensive database for single-cell perturbation data analysis and visualization

PerturBase is a database that compiles and visualizes single-cell perturbation data from multiple studies, enabling analysis of genetic and chemical perturbations across millions of cells.

Switching circuits: Modulating NK cell response to TGF-β using novel receptors

This study identifies novel switch receptors for NK cells that enhance cytotoxicity and persistence in the presence of TGF-β through a pooled screening approach.

The Discovery and Characterization of 1,4-Dihydroxy-2-naphthoic Acid Prenyltransferase Involved in the Biosynthesis of Anthraquinones in Rubia cordifolia

This study identifies and characterizes RcDT1, a prenyltransferase involved in anthraquinone biosynthesis in Rubia cordifolia, and shows its evolutionary origin from the ubiquinone pathway.

Autoantibodies against eukaryotic translation elongation factor 1 delta (EEF1D) in two patients with autoimmune cerebellar ataxia

This study identifies anti-EEF1D autoantibodies in two patients with autoimmune cerebellar ataxia, suggesting their potential as a biomarker for diagnosis and recurrence prevention.

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

Electrostatic modulation of signaling at cell membrane: Waveform- and time-dependent electric control of ERK dynamics

This study shows that alternating current electric fields can modulate ERK signaling in epithelial cells through waveform- and timing-dependent electrostatic interactions.

TRAFfic signals: High-throughput CAR discovery in NK cells reveals novel TRAF-binding endodomains that drive enhanced persistence and cytotoxicity

This study identifies TRAF-binding endodomains that enhance CAR NK cell persistence and cytotoxicity through high-throughput screening.

Structural basis for auto-inhibition and activation of a short prokaryotic Argonaute associated TIR-APAZ defense system

The paper determines cryo-EM structures of SPARTA in different states to elucidate its auto-inhibition and activation mechanisms.

Fus3 interacts with Gal83, revealing the MAPK crosstalk to Snf1/AMPK to regulate secondary metabolic substrates in filamentous fungi

This paper identifies Gal83 as a target of Fus3-MAPK and shows it regulates aflatoxin synthesis substrates through crosstalk with Snf1/AMPK in Aspergillus flavus.

Remodeling the central metabolism of Escherichia coli enables a universal chassis

This paper describes the construction of an E. coli strain with suppressed overflow metabolism, leading to improved chemical and protein production.

Attractant and repellent induce opposing changes in the chemoreceptor four-helix bundle ligand-binding domain

The paper identifies malate as a repellent recognized by the MCP2021 chemoreceptor in Comamonas testosteroni and shows how it induces opposing conformational changes compared to the attractant citrate.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis

This study shows CD99 regulates protein synthesis in hematopoietic stem cells and leukemia stem cells, promoting self-renewal and clonal expansion leading to AML.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

A cinnamyl alcohol dehydrogenase (CAD) like enzyme leads to a branch in the shikonin biosynthetic pathway in Arnebia euchroma

This study identifies AeHGO, a CAD-like enzyme, as the branch point enzyme in the shikonin biosynthetic pathway of A. euchroma, showing it catalyzes reversible oxidation/reduction of key intermediates.

ENHANCED GRAVITROPISM 2 coordinates molecular adaptations to gravistimulation in the elongation zone of barley roots

This study identifies EGT2 as a central regulator of gravitropic responses in barley roots by analyzing transcriptomic changes and interaction networks in response to gravistimulation.

Integrative multispecies omics reveals a hierarchy of cold-responsive regulatory network launched by circadian components in rosids

This study identifies conserved cold-responsive regulators and their regulatory networks across three rosid species, revealing a hierarchical control involving circadian components.

Evolution of insecticide resistance via parallel amino acid substitutions in insect pests and their parasitoid wasps

The paper identifies parallel amino acid substitutions at the Rdl gene in insect pests and their parasitoid wasps, showing how resistance to insecticides evolves in both species.

The effector recognition by synthetic sensor NLR receptors requires the concerted action of multiple interfaces within and outside the integrated domain

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

Telomere dysfunction impairs intestinal differentiation andpredisposes to diet-induced colitis

This study shows that telomere shortening impairs intestinal differentiation, leading to barrier defects and diet-induced colitis through microbiome modulation and nutrient flux.

Identification of novel basil downy mildew resistance genes using de novo comparative transcriptomics

This study identifies novel resistance genes against basil downy mildew using comparative transcriptomics in resistant and susceptible plants.

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

The tissue-specific chromatin accessibility landscape of Papaver somniferum

This study identifies tissue-specific chromatin accessibility and gene expression in Papaver somniferum to uncover regulatory mechanisms for morphine and noscapine accumulation.

Inhibition of the IL-17A axis Protects against Immune-related Adverse Events while Supporting Checkpoint Inhibitor Anti-tumor Efficacy

This study shows that inhibiting the IL-17A axis reduces immune-related adverse events in checkpoint inhibitor-treated mice without affecting anti-tumor efficacy.

Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.