Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein
S. Tetter, N. Terasaka, A. Steinauer, R. J. Bingham, S. Clark, A. J. P. Scott, N. Patel, M. Leibundgut, E. Wroblewski, N. Ban, P. G. Stockley, R. Twarock, D. Hilvert
This study evolved a bacterial protein into an artificial nucleocapsid that packages and protects mRNA, revealing evolutionary parallels to viruses and potential applications in vaccine delivery.
bioRxiv · Dec 23, 2020Biochemistry