Author

R. Twarock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

F. Fatehi· 3 shared N. Patel· 3 shared P. G. Stockley· 3 shared S. Clark· 2 shared A. Antanasijevic· 1 shared A. J. Borst· 1 shared A. J. P. Scott· 1 shared A. J. R. Heck· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

F. Fatehi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages

T. N. Szyszka, M. P. Andreas, F. Lie, L. M. Miller, L. S. R. Adamson, F. Fatehi, R. Twarock, B. E. Draper, M. F. Jarrold, T. W. Giessen, Y. H. Lau

The paper shows that a single point mutation in a virus-like capsid can drive the formation of tetrahedral structures instead of the typical icosahedral symmetry.

bioRxiv · Feb 5, 2024Biochemistry

Local structural flexibility drives oligomorphism in computationally designed protein assemblies

A. Khmelinskaia, N. P. Bethel, F. Fatehi, A. Antanasijevic, A. J. Borst, S.-H. Lai, J. Y. Wang, B. Basu Mallik, M. M. Miranda, A. M. Watkins, C. Ogohara, S. Caldwell, M. Wu, A. J. R. Heck, D. Veesler, , N. P. King

This study shows that structural flexibility in computationally designed protein assemblies leads to multiple architectures, expanding their functional possibilities.

bioRxiv · Oct 18, 2023Bioengineering

In vitro Functional Analysis of pgRNA Sites Regulating Assembly of Hepatitis B Virus.

N. Patel, S. Clark, E. U. Weiss, C. P. Mata, J. Bohon, E. Farquhar, D. P. Maskell, N. A. Ranson, R. Twarock, P. G. Stockley

The paper investigates RNA sequence/structure motifs regulating HBV genome assembly in vitro, showing their role in nucleocapsid formation and confirming interactions via X-ray RNA footprinting.

bioRxiv · Sep 8, 2021Microbiology

Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands

N. Patel, F. Abulwerdi, F. Fatehi, I. Manfield, S. Le Grice, J. S. Schneekloth, R. Twarock, P. G. Stockley

The paper identifies small ligands that bind RNA packaging signals in Hepatitis B Virus, inhibiting nucleocapsid assembly and suggesting new anti-viral drug targets.

bioRxiv · Aug 10, 2021 · PreprintMicrobiology

Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein

S. Tetter, N. Terasaka, A. Steinauer, R. J. Bingham, S. Clark, A. J. P. Scott, N. Patel, M. Leibundgut, E. Wroblewski, N. Ban, P. G. Stockley, R. Twarock, D. Hilvert

This study evolved a bacterial protein into an artificial nucleocapsid that packages and protects mRNA, revealing evolutionary parallels to viruses and potential applications in vaccine delivery.

bioRxiv · Dec 23, 2020Biochemistry