S. Clark

Single molecule studies of the native hair cell mechanosensory transduction complex

This study optimizes single molecule assays to detect and quantify the native hair cell mechanosensory transduction complex at attomole levels.

Structure of C. elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction

The paper presents the cryo-EM structure of the C. elegans TMC-2 complex and compares it to the TMC-1 complex to identify structural features involved in mechanosensory transduction.

Single cell DNA methylation ageing in mouse blood

This study develops a single-cell DNA methylation age predictor using a large multi-omics dataset from mouse blood, revealing epigenetic age heterogeneity and differences across blood cell types.

Structure of C. elegans TMC-1 complex illuminates auditory mechanosensory transduction

The paper determines the structure of the C. elegans TMC-1 complex using cryo-EM, revealing its composition and mechanism of mechanosensory transduction.

Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

This study shows hypoxia suppresses type I interferon signaling in ALI, leading to monocytopenia and unchecked inflammation, which can be mitigated by CSF1 administration.

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

In vitro Functional Analysis of pgRNA Sites Regulating Assembly of Hepatitis B Virus.

The paper investigates RNA sequence/structure motifs regulating HBV genome assembly in vitro, showing their role in nucleocapsid formation and confirming interactions via X-ray RNA footprinting.

Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein

This study evolved a bacterial protein into an artificial nucleocapsid that packages and protects mRNA, revealing evolutionary parallels to viruses and potential applications in vaccine delivery.

Rapid generation of potent antibodies by autonomous hypermutation in yeast

This paper introduces AHEAD, a yeast-based system for rapid antibody generation through autonomous hypermutation, achieving high-affinity antibodies against SARS-CoV-2 and other targets in just 2 weeks.

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

Iron-sulfur cluster repair contributes to Y. pseudotuberculosis survival within deep tissues

This study shows that Y. pseudotuberculosis uses Fe-S cluster repair via YtfE to survive in the spleen under nitrosative stress, even when NO detoxification is absent.

MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ Breast Cancer

The paper shows that miR-196a is regulated by ER and serves as a prognostic biomarker in ER+ breast cancer.