Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
K. Yamada, V. N. Hariharan, J. Caiazzi, R. Miller, C. Ferguson, E. Sapp, H. Fakih, Q. Tan, N. Yamada, R. Furgal, J. Paquette, B. Bramato, N. McHugh, A. Summer, C. Lochmann, , A. Khvorova
This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.
bioRxiv · May 26, 2023Biochemistry