Author

Q. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 2 Cell Biology· 2 Evolutionary Biology· 2 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 8 Approach:experimental assay· 7 Organism:human· 7 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

H. Zhang· 3 shared Q. Zhang· 3 shared Y. Zhu· 3 shared B. Wu· 2 shared D. J. Tschumperlin· 2 shared D. L. Jones· 2 shared G. Ligresti· 2 shared H. Yan· 2 shared

Activity by Year

2018-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

H. Zhang

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

Z. Ou, L. Li, P. Ren, T. Zhou, F. He, J. Chen, H. Cai, X. Han, Y. Wu, J. Li, X. Li, Q. Tan, W. Li, Q. Chen, N. Zhang, , H. Yan

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Advanced Science · Feb 22, 2025Peer-reviewedImmunology

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

C. Lian, C. Zhang, P. Tian, Q. Tan, Y. Wei, Q. Zhang, Z. Wang, Q. Zhang, M. Zhong, L.-Q. Zhou, X. Ke, H. Zhang, Y. Zhu, Z. Li, J. Cheng, G.-H. Wei

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

Signal Transduction and Targeted Therapy · Sep 28, 2024Peer-reviewedCancer Biology

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

X. Hu, W. Ao, M. Gao, L. Wu, Y. Pei, S. Liu, Q. Sun, J. Liu, L. Jiang, Y. Wu, X. Wang, Y. Li, Q. Tan, J. Cheng, F. Yang, , Z. Liu

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

bioRxiv · Apr 13, 2024 · PreprintBiophysics

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

K. Yamada, V. N. Hariharan, J. Caiazzi, R. Miller, C. Ferguson, E. Sapp, H. Fakih, Q. Tan, N. Yamada, R. Furgal, J. Paquette, B. Bramato, N. McHugh, A. Summer, C. Lochmann, , A. Khvorova

This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.

bioRxiv · May 26, 2023Biochemistry

Selection and validation of internal control genes for quantitative real-time RT-qPCR normalization of Phlebopus portentosus gene expression under different conditions

C.-M. Hu, C.-H. Li, T. Guo, G.-Y. Ji, S.-Z. Luo, Y. Cao, K.-P. Ji, Q. Tan, D.-P. Bao, R.-H. Yang

This study identifies stable reference genes for RT-qPCR normalization in Phlebopus portentosus under different conditions and developmental stages.

bioRxiv · Oct 19, 2022 · PreprintMicrobiology

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

N. Hou, L. Shuai, L. Zhang, X. Xie, K. Tang, Y. Zhu, Y. Yu, W. Zhang, Q. Tan, G. Zhong, Z. Wen, C. Wang, X. He, H. Huo, H. Gao, , Q. Hu

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

bioRxiv · Aug 10, 2022 · PreprintMicrobiology

Two shifts in evolutionary lability underlie independent gains and losses of root-nodule symbiosis in a single clade of plants

H. Kates, B. C. O'Meara, R. LaFrance, G. W. Stull, E. K. James, S. Liu, Q. Tan, T. Yi, J.-M. Ane, D. Conde, M. Kirst, D. E. Soltis, R. P. Guralnick, P. S. Soltis, R. A. Folk

The paper reconstructs the evolutionary history of root-nodule symbiosis in the nitrogen-fixing clade, identifying a two-step process involving shifts in evolutionary lability that explain multiple independent gains and losses of the trait.

bioRxiv · Jul 31, 2022 · PreprintEvolutionary Biology

Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury

D. L. Jones, N. Caporarello, J. A. Meridew, K. M. Choi, A. J. Haak, P. A. Link, Q. Tan, T. Ordog, G. Ligresti, D. J. Tschumperlin

This study shows that lung mesenchyme retains epigenetic memory of prior injury, leading to amplified fibrogenic responses upon re-injury, with Runx1 playing a key role.

bioRxiv · Mar 4, 2022Cell Biology

Structures of the human cholecystokinin receptors in complex with agonists and antagonists

X. Zhang, C. He, M. Wang, Q. zhou, D. Yang, Y. Zhu, W. Feng, H. Zhang, A. Dai, X. Chu, J. Wang, Z. Yang, Y. Jiang, U. Sensfuss, Q. Tan, , Q. Zhao

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

bioRxiv · May 19, 2021 · PreprintBiophysics

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

D. L. Jones, J. A. Meridew, M. T. Ducharme, K. L. Lydon, K. M. Choi, N. Caporarello, Q. Tan, P. A. Link, A. M. Diaz Espinosa, Y. Xiong, J.-H. Lee, Z. Ye, H. Yan, T. Ordog, G. Ligresti, , D. J. Tschumperlin

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

bioRxiv · Jul 23, 2020Cell Biology

Integrated technology platform for accelerated discovery of antiviral antibody therapeutics

P. Gilchuk, R. G. Bombardi, J. H. Erasmus, Q. Tan, R. S. Nargi, C. Soto, P. Abbink, T. J. Suscovich, L. A. Dunellin, A. Khandhar, J. Archer, J. Liang, M. E. Fouch, E. Davidson, B. Doranz, , R. H. Carnahan

This study develops an integrated platform to rapidly discover and validate potent antiviral human monoclonal antibodies against Zika virus.

bioRxiv · May 12, 2020Immunology

A Small-Bodied Troodontid (Dinosauria, Theropoda) from the Upper Cretaceous Wulansuhai Formation of Inner Mongolia, China

S. WANG, Q. Tan, Q. Zhang, J. Stiegler, H. Zhang, L. Tan

The paper describes a new small-bodied troodontid dinosaur from the Upper Cretaceous of Inner Mongolia and confirms its phylogenetic position through analysis.

bioRxiv · Feb 5, 2020 · PreprintEvolutionary Biology

Rapid CD4 cell loss is caused by specific CRF01_AE cluster with V3 signatures favoring CXCR4 usage

H. Song, W. Ou, Y. Feng, J. Zhang, F. Li, J. Hu, H. Peng, H. Xing, L. Ma, Q. Tan, B. Wu, Y. Shao

The paper identifies a specific CRF01_AE HIV-1 phylogenetic cluster associated with rapid CD4 cell loss and higher prevalence of CXCR4-using viruses.

bioRxiv · Sep 26, 2018 · PreprintMicrobiology