Author

S. Shan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 2 Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Research Focus:clustering· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

L. Zhang· 6 shared X. Wang· 6 shared J. Ge· 4 shared J. Yu· 4 shared Q. Zhang· 4 shared X. Shi· 4 shared J. Lan· 3 shared L. Liu· 3 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

L. Zhang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

X. Li, Y. Pan, Q. Yin, Z. Wang, S. Shan, L. Zhang, J. Yu, Y. Qu, L. Sun, F. Gui, J. Lu, Z. Jing, W. Wu, T. Huang, X. Shi, , X. Wang

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

bioRxiv · May 27, 2022Biochemistry

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

M. Li, Y. Ren, Z. Q. Aw, B. Chen, Z. Yang, Y. Lei, L. Cheng, Q. Liang, J. Hong, Y. Yang, J. Chen, Y. H. Wong, S. Shan, S. Zhang, J. Ge, , L. Zhang

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

bioRxiv · Apr 12, 2022 · PreprintImmunology

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

B. Zhou, R. Zhou, J. F.-W. Chan, J. Zeng, Q. Zhang, S. Yuan, L. Liu, R. Robinot, S. Shan, J. Ge, H. Y.-H. Kwong, D. Zhou, H. Xu, C. C.-S. Chan, V. K.-M. Poon, , Z. Chen

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

D. Tong, M. Zhang, Y. Yang, H. Xia, H. Tong, H. Zhang, W. Zeng, M. Liu, Y. Wu, H. Ma, X. Hu, W. Liu, Y. Cai, Y. Yao, Y. Yao, , T. Xue

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

bioRxiv · May 19, 2021Immunology

SlicerMorph: An open and extensible platform to retrieve, visualize and analyze 3D morphology

S. Rolfe, S. Pieper, A. Porto, K. Diamond, J. Winchester, S. Shan, H. Kirveslahti, D. Boyer, A. Summer, A. M. Maga

SlicerMorph provides an open platform for retrieving, visualizing, and analyzing 3D morphology data to address challenges in quantitative organismal biology research.

bioRxiv · Nov 9, 2020Evolutionary Biology

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution

X. Wang, S. Zhang, S. Qiao, J. Yu, J. Zeng, S. Shan, J. Lan, L. Tian, L. Zhang

The paper determines cryo-EM structures of bat and pangolin coronavirus spikes, showing PCoV_GX spike binds human ACE2 like SARS-CoV-2, while RaTG13 does not, and identifies key residues and glycans involved in RBD function.

bioRxiv · Sep 21, 2020Biophysics

Potent human neutralizing antibodies elicited by SARS-CoV-2 infection

B. Ju, Q. Zhang, X. Ge, R. Wang, J. Yu, S. Shan, B. Zhou, S. Song, X. Tang, J. Yu, J. Ge, J. Lan, J. Yuan, H. Wang, J. Zhao, , L. Zhang

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

bioRxiv · Mar 21, 2020Immunology

Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor

J. Lan, J. Ge, J. Yu, S. Shan, H. Zhou, S. Fan, Q. Zhang, X. Shi, Q. Wang, L. Zhang, X. Wang

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

bioRxiv · Feb 19, 2020Biophysics

AhRLK1, a CLAVATA1-like leucine-rich repeat receptor-like kinase of peanut, confers increased resistance to bacterial wilt in tobacco

C. Zhang, H. Chen, R.-R. Zhuang, Y.-T. Chen, Y. Deng, T.-C. Cai, S.-Y. Wang, Q.-Z. Liu, R.-H. Tang, S. Shan, R.-L. Pan, L.-S. Chen, W.-J. Zhuang

This study identifies AhRLK1, a peanut receptor-like kinase, which enhances resistance to Ralstonia solanacearum in tobacco through hypersensitive response and hormone signaling.

bioRxiv · Sep 28, 2018Plant Biology