BiochemistrybioRxiv
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo
K. Yamada, V. N. Hariharan, J. Caiazzi…·A. Khvorova
This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.
DOI 10.1038/s41587-024-02336-7