Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as PfCDPK1 kinase inhibitors
I. Irfan, A. Uddin, R. Jain, A. Gupta, S. Gupta, J. V. Napoleon, A. Hussain, M. F. Alajmi, M. C. Joshi, P. Hasan, M. Abid, S. Singh
This study evaluates novel CQTrICh-analogs as antimalarials, showing they inhibit Plasmodium falciparum strains and target PfCDPK1 kinase with selectivity over human kinases.
bioRxiv · Jul 7, 2022Biochemistry