A. Hussain

2-bromo-2',5'-dihydroxychalcone analogue Inhibits Endothelial Migration by Targeting VEGF-induced ERK 1/2 Phosphorylation

This paper evaluates a 2-bromo-2',5'-dihydroxychalcone analogue (AH9) for its ability to inhibit endothelial cell migration by blocking VEGF-induced ERK1/2 phosphorylation, showing comparable efficacy to Sorafenib.

The rural urban divide, insights from immuno-genetic profiles and implications for health

The paper analyzes genotype and gene expression differences between rural and urban populations in eastern Sudan, finding higher cytokine expression and genetic variation in rural samples linked to health disparities.

Comparative Analysis, Diversification and Functional Validation of Plant Nucleotide-Binding Site Domain Genes

This study identifies and classifies NBS domain genes across 34 plant species, revealing structural diversity and functional roles in plant-pathogen interactions.

Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress

This study identifies RNase R's role in protecting Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress through its RNB domain, independent of its exoribonuclease activity or degradosome association.

A novel resistance reversion mechanism in a vancomycin-variable Enterococcus faecium strain

The paper identifies a vancomycin-variable Enterococcus faecium isolate that reverts to resistance via a novel mechanism involving vanHAX gene activation through genomic rearrangements.

A new competitive strategy to unveil the antibiotic-producing Actinobacteria

This paper introduces a competitive strategy to enhance antibiotic-producing Actinobacteria strain isolation by leveraging microbial interactions, resulting in strains with distinct antimicrobial properties.

Functional antagonistic interactions and genomic insights into the biosynthetic potential of human gut-derived microbiota

The paper identifies antagonistic interactions and biosynthetic gene clusters in human gut microbiota, highlighting their therapeutic potential and role in combating antibiotic resistance.

BBIBP-CorV (Sinopharm) vaccination- induced immunity is affected by age, gender and prior COVID-19 and activates responses to spike and other antigens

This study examines how BBIBP-CorV vaccination-induced immunity varies with age, gender, and prior COVID-19, showing differential antibody and T cell responses to SARS-CoV-2 antigens.

Risk Assessment of the newly emerged H7N9 avian influenza viruses

This study assesses the zoonotic risk of recent H7N9 avian influenza viruses by analyzing their receptor binding, stability, and immune escape properties compared to earlier strains.

Temporal Vascular Endothelial Growth Factor Sub-type gene Switching in SARS-CoV Pathogenesis. Interpretation through in vivo Murine C57BL Models

This study analyzes temporal gene expression patterns of VEGF-A and VEGF-B in a murine SARS-CoV model, revealing dynamic changes and potential interactions with SARS-CoV-2 Spike protein.

Role of DEAD Box RNA helicases in low temperature adapted growth of Antarctic Pseudomonas syringae Lz4W

The paper investigates the role of DEAD box RNA helicases in cold adaptation of Antarctic Pseudomonas syringae, finding that srmB and dbpA are important for cold growth while csdA is essential, and rhlB and rhlE are not involved.

Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as PfCDPK1 kinase inhibitors

This study evaluates novel CQTrICh-analogs as antimalarials, showing they inhibit Plasmodium falciparum strains and target PfCDPK1 kinase with selectivity over human kinases.

P2RX7 inhibition reduces breast cancer induced osteolytic lesions - implications for bone metastasis

This study shows that inhibiting P2RX7 reduces osteolytic lesions in a murine breast cancer model by increasing cancer cell death and decreasing osteoclast numbers.

CaPti1/CaERF4 module positively regulates pepper resistance to bacterial wilt disease through coupling enhanced immunity and dehydration tolerance

This study identifies the CaPti1-CaERF4 module as a regulator that couples immunity and dehydration tolerance in pepper plants to enhance resistance to bacterial wilt disease.

Single-Domain SARS-CoV-2 S1 and RBD Antibodies Isolated from Immunized Llama Effectively Bind Targets of the Wuhan, UK, and South African Strains in vitro

The paper validates that single-domain antibodies bind RBD of SARS-CoV-2 from original, UK, and South African variants, ensuring their effectiveness in antigen detection tests.

Redefining colorectal cancer classification and clinical stratification through a single-cell atlas

This paper constructs a single-cell transcriptome atlas of colorectal cancer to reveal subclonal heterogeneity and identify CAF subtypes associated with survival and immunotherapy resistance.

Population structure, biogeography and transmissibility of Mycobacterium tuberculosis

This study analyzes the population structure, biogeography, and transmissibility of Mycobacterium tuberculosis using genomic data from thousands of strains, identifying new clades and sub-lineages.

In Lyl1-/- mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues

This study shows that Lyl1 deficiency in mice causes vascular niche impairment in adipose tissue, leading to premature adipocyte differentiation and fat tissue expansion.

Cotton growth, yield, quality and boron distribution as affected by soil-applied boron in calcareous saline soil

This study investigates the effects of soil-applied boron on cotton growth, yield, quality, and boron distribution in calcareous saline soils, finding that 2.60 mg B kg-1 significantly improves these traits.

Bacteriophages can be used as infection control agents: A proof-of concept study involving anti-Acinetobacter baumannii phage

This study demonstrates that bacteriophages can effectively reduce XDR Acinetobacter baumannii on solid surfaces, serving as a potential infection control agent.

Phytohormonal cross-talk modulate Bipolaris sorokiniana (Scc.)interaction with Zea mays

The paper investigates how GA3 levels modulate maize's interaction with Bipolaris sorokiniana, showing that high GA3 inhibits colonization while low GA3 promotes it.

Distinct cancer-associated fibroblast states drive clinical outcomes in high-grade serous ovarian cancer and are regulated by TCF21

This study identifies two distinct cancer-associated fibroblast subtypes in high-grade serous ovarian cancer and shows their differential impact on patient outcomes and tumor progression.

Structural and functional impact of non- synonymous SNPs in the CST complex subunit TEN1: Structural genomics approach

The paper investigates the structural and functional impact of non-synonymous SNPs in the TEN1 gene using computational tools to identify deleterious mutations and their effects on protein stability and function.

An Automated Workflow for Segmenting Single Adult Cardiac Cells from Large-Volume Serial Block-Face Scanning Electron Microscopy Data

This paper introduces an automated algorithm to segment cardiac cell structures from SBF-SEM data, achieving 97% accuracy and enabling 3D finite element mesh generation for computational physiology studies.