Author

A. van Hoeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:variant calling· 3 Research Focus:variant effect prediction· 3 Assay:whole-genome sequencing· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

E. Cuppen· 4 shared J. Martens· 2 shared P. Priestley· 2 shared B. vd Roest· 1 shared C. Shale· 1 shared C. van Herpen· 1 shared Center for Personalized Cancer Treatment· 1 shared E. de Bruijn· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCancer Biology

E. Cuppen

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4 papers

Recent·Most cited

Learning mutational signatures and their multidimensional genomic properties with TensorSignatures

H. Vohringer, A. van Hoeck, E. Cuppen, M. Gerstung

This paper introduces TensorSignatures, an algorithm that jointly learns mutational signatures across mutation types and genomic context, revealing new insights into mutational processes in cancer.

bioRxiv · Jun 19, 2020Cancer Biology

Pan-cancer landscape of homologous recombination deficiency

L. Nguyen, J. Martens, A. van Hoeck, E. Cuppen

This study develops a pan-cancer Classifier of Homologous Recombination Deficiency (CHORD) and identifies HRD frequency and genetic causes across multiple cancer types.

bioRxiv · Jan 13, 2020Cancer Biology

Pan-cancer whole genome analyses of metastatic solid tumors

P. Priestley, J. Baber, M. Lolkema, N. Steeghs, E. de Bruijn, K. Duyvesteyn, S. Haidari, A. van Hoeck, W. Onstenk, P. Roepman, C. Shale, M. Voda, H. Bloemendal, V. Tjan-Heijnen, C. van Herpen, , E. Cuppen

This study analyzes whole genome sequences of metastatic solid tumors to identify genetic variants that may influence treatment outcomes.

bioRxiv · Aug 12, 2019 · PreprintCancer Biology

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

S. Christensen, B. vd Roest, N. Besselink, R. Janssen, S. Boymans, J. Martens, M.-L. Yaspo, P. Priestley, Center for Personalized Cancer Treatment, E. Kuijk, E. Cuppen, A. van Hoeck

This study shows that 5-FU treatment causes characteristic T>G mutations in cancer, similar to endogenous mutational signatures, and may increase secondary malignancy risk.

bioRxiv · Jun 25, 2019Cancer Biology