Author

E. Kuijk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Research Focus:variant calling· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

E. Cuppen· 3 shared N. Besselink· 3 shared P. Priestley· 2 shared R. Janssen· 2 shared S. Boymans· 2 shared A. Borgman· 1 shared A. van Hoeck· 1 shared B. M. Faltas· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

E. Cuppen

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3 papers

Recent·Most cited

Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

J. Vlaar, A. Borgman, E. Kalkhoven, D. Westland, N. Besselink, C. Shale, B. M. Faltas, P. Priestley, E. Kuijk, E. Cuppen

This study identifies AHR{Delta}e8-9 as a novel driver mutation in urinary tract cancer, leading to ligand-independent pathway activation and tumorigenic properties in bladder organoids.

bioRxiv · Nov 9, 2021Cancer Biology

Mutational impact of chronic alcohol use on stem cells in cirrhotic liver

M. Jager, E. Kuijk, R. Lieshout, M. Locati, N. Besselink, B. van der Roest, R. Janssen, S. Boymans, J. de Jonge, J. IJzermans, M. Doukas, M. Verstegen, R. van Boxtel, L. van der Laan, E. Cuppen

This study investigates the mutational impact of chronic alcohol use on liver stem cells in cirrhotic livers and finds no alcohol-specific mutational signatures but identifies enriched oncogenic mutations in cancer genes.

bioRxiv · Jul 11, 2019 · PreprintCancer Biology

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

S. Christensen, B. vd Roest, N. Besselink, R. Janssen, S. Boymans, J. Martens, M.-L. Yaspo, P. Priestley, Center for Personalized Cancer Treatment, E. Kuijk, E. Cuppen, A. van Hoeck

This study shows that 5-FU treatment causes characteristic T>G mutations in cancer, similar to endogenous mutational signatures, and may increase secondary malignancy risk.

bioRxiv · Jun 25, 2019Cancer Biology