Author

B. vd Roest

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. van Hoeck· 1 shared Center for Personalized Cancer Treatment· 1 shared E. Cuppen· 1 shared E. Kuijk· 1 shared J. Martens· 1 shared M.-L. Yaspo· 1 shared N. Besselink· 1 shared P. Priestley· 1 shared

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2019-2019 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. van Hoeck

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1 paper

Recent·Most cited

Cancer BiologybioRxivJun 25, 2019

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

S. Christensen, B. vd Roest, N. Besselink…·A. van Hoeck

This study shows that 5-FU treatment causes characteristic T>G mutations in cancer, similar to endogenous mutational signatures, and may increase secondary malignancy risk.

DOI 10.1038/s41467-019-12594-8

humanwhole-genome sequencing

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