Author

C. Shale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Research Focus:variant calling· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

E. Cuppen· 3 shared P. Priestley· 3 shared J. Baber· 2 shared A. Borgman· 1 shared A. T. Papenfuss· 1 shared A. van Hoeck· 1 shared B. M. Faltas· 1 shared C. van Herpen· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

E. Cuppen

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Author profile →

3 papers

Recent·Most cited

Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

J. Vlaar, A. Borgman, E. Kalkhoven, D. Westland, N. Besselink, C. Shale, B. M. Faltas, P. Priestley, E. Kuijk, E. Cuppen

This study identifies AHR{Delta}e8-9 as a novel driver mutation in urinary tract cancer, leading to ligand-independent pathway activation and tumorigenic properties in bladder organoids.

bioRxiv · Nov 9, 2021Cancer Biology

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

C. Shale, J. Baber, D. Cameron, M. Wong, M. J. Cowley, A. T. Papenfuss, E. Cuppen, P. Priestley

This paper introduces LINX, a tool for analyzing structural variation and copy number alterations in cancer genomes, revealing novel insights into oncogenic fusions and inactivation events.

bioRxiv · Dec 3, 2020Cancer Biology

Pan-cancer whole genome analyses of metastatic solid tumors

P. Priestley, J. Baber, M. Lolkema, N. Steeghs, E. de Bruijn, K. Duyvesteyn, S. Haidari, A. van Hoeck, W. Onstenk, P. Roepman, C. Shale, M. Voda, H. Bloemendal, V. Tjan-Heijnen, C. van Herpen, , E. Cuppen

This study analyzes whole genome sequences of metastatic solid tumors to identify genetic variants that may influence treatment outcomes.

bioRxiv · Aug 12, 2019 · PreprintCancer Biology