Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy
E. Njomen, T. Lansdell, A. Vanecek, V. Benham, M. Bernard, Y.-T. Yang, P. Schall, D. Isaac, O. Alkharabsheh, A. Al-Janadi, m. Giletto, E. Elsworth, C. Taylor, T. Yang, m. Bailie, , J. Tepe
This study shows that activating the 20S proteasome with small molecules reduces c-MYC-driven cancer growth in vitro and in vivo, including in bortezomib-resistant cells.
bioRxiv · Aug 24, 2020 · PreprintPharmacology & Toxicology