Pharmacology & ToxicologybioRxivPreprint
Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy
E. Njomen, T. Lansdell, A. Vanecek…·J. Tepe
This study shows that activating the 20S proteasome with small molecules reduces c-MYC-driven cancer growth in vitro and in vivo, including in bortezomib-resistant cells.