T. Yang

Intestinal serotonergic vagal signaling as a mediator of microbiota-induced hypertension

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Protein S-glutathionylation confers cell resistance to ferroptosis

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

Metabolic engineering of narrow-leafed lupin for the production of enantiomerically pure (-)-sparteine

This study engineered narrow-leafed lupin to produce enantiomerically pure (-)-sparteine by knocking out a key enzyme, achieving 99% enantiomeric excess.

Top-down Mass Spectrometric Analysis of a Lipooligosaccharide from the Human Commensal Bacteroides fragilis

This study uses top-down mass spectrometry to determine the detailed structure of B. fragilis lipooligosaccharide, revealing its poly-galactose-rhamnose-KDO-lipid A architecture and modifications.

Cryo-EM structures of human cone visual pigments

This study presents cryo-EM structures of human cone visual pigments in complex with G proteins, revealing their active state and mutations affecting spectral tuning.

YamOmics: A comprehensive data resource on yam multi-omics

YamOmics compiles and organizes multi-omics data from 41 yam species, providing genomic, transcriptomic, and plastomic data along with variant and expression information for yam research and breeding.

Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)

This study uses scRNA-seq to analyze theanine metabolism in tea plant roots, revealing multicellular compartmentation of biosynthesis without high co-expression of transcription factors.

Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways

This study identifies a feedback loop between viperin and VHSV where viperin degrades viral proteins via autophagy, while viral N protein suppresses viperin via proteasome degradation.

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

Identification of a short, single site matriglycan that maintains neuromuscular function in the mouse

The paper identifies a shorter matriglycan on dystroglycan that maintains neuromuscular function in adult mice and protects skeletal muscle from damage.

Bioactive coatings on 3D printed polycaprolactone scaffolds for bone regeneration: a novel murine femur defect model for examination of the biomaterial capacity for repair.

This study evaluates bioactive coatings on 3D printed PCL-TMA900 scaffolds for bone regeneration using a murine femur defect model, finding that Laponite/BMP-2 coating significantly promotes bone formation without heterotopic bone formation.

Cellular Lipids Regulate the Conformational Ensembles of the Disordered Intracellular Loop 3 in beta-2 Adrenergic Receptor

This study shows that lipids like PIP2 and GM3 modulate the conformation of ICL3 in beta-2AR, affecting G protein coupling through membrane tilting and allosteric effects.

Electronic Polarizability Tunes the Function of the Human Bestrophin 1 Cl- Channel

The paper shows that electronic polarization is essential for accurately simulating Cl- permeation through the hBest1 channel and resolving ion-like densities in cryo-EM structures.

Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite™ to deliver BMP-2 for bone tissue engineering - progression through in vitro, chorioallantoic membrane assay and murine subcutaneous model validation.

This paper evaluates Laponite-coated scaffolds for delivering BMP-2 to enhance bone regeneration, showing effective osteoinduction in vitro and in vivo with delayed use.

Bioactive coatings on 3D printed scaffolds for bone regeneration: Translation from in vitro to in vivo models and the impact of material properties and growth factor concentration.

This study evaluates bioactive coatings on 3D-printed PCL-TMA scaffolds for bone regeneration, showing in vitro osteogenic response but no significant in vivo bone formation.

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

The paper presents cryo-EM structures of human SIDT1 and SIDT2, revealing their dimeric architecture and demonstrating low-pH-dependent RNA binding and oligomerization.

Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

This study maps N-glycosylation sites in SIDT1 and SIDT2 and shows their role in RNA uptake, cell surface expression, and protein stability.

Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery

The paper maps 3D genome structures in cancer tissues to identify structural changes and potential biomarkers across cancer progression stages.

De novo progesterone synthesis in plants

This study identifies the complete pathway for progesterone biosynthesis in Marsdenia tenacissima, involving specific P450scc and MtHSD5 enzymes, enabling sustainable steroid hormone drug synthesis.

Long-Distance Electron Transport in Multicellular Freshwater Cable Bacteria

This paper measures and quantifies the electronic conductivity of freshwater cable bacteria, revealing their high conductivity and the role of nanofiber networks in long-distance electron transport.

Association between the rifampicin resistance mutations and rifabutin susceptibility in Mycobacterium tuberculosis: a meta-analysis

This study identifies RIF-resistance mutations in M. tuberculosis associated with rifabutin susceptibility through a meta-analysis of 25 studies.

Roles of Lipopolysaccharide Glycosyltransferases in Maintenance of Helicobacter pylori Morphology, Cell Wall Permeability, and Antimicobial Susceptibilities

This study investigates the roles of LPS glycosyltransferases in H. pylori morphology, cell wall permeability, and antimicrobial susceptibility, finding that their deletion alters morphology and increases susceptibility to certain antimicrobials.

Tomato CYP94C1 terminates jasmonate signaling during fruit ripening by inactivating bioactive jasmonoyl-L-isoleucine

This study identifies CYP94C1 as a key enzyme in tomato that terminates jasmonate signaling during ripening by converting bioactive JA-Ile to an inactive form, thereby reducing susceptibility to necrotrophic pathogens.

Targeting Sex Determination to Suppress Mosquito Populations

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

Enriched zones of embedded ribonucleotides are associated with DNA replication and coding sequences in the human mitochondrial genome

The paper identifies rNMP-enriched zones in human mtDNA linked to replication and coding sequences using ribose-seq across six cell types.

An improved Nicotiana benthamiana bioproduction chassis provides novel insights into nicotine biosynthesis

This study improves Nicotiana benthamiana for bioproduction by reducing nicotine levels and provides insights into the role of BBLs in nicotine biosynthesis.

Multifunctional Materials Strategies for Enhanced Safety of Wireless, Skin-Interfaced Bioelectronic Devices

This paper introduces a self-healing PDMS material with safety-enhancing properties for wireless, skin-interfaced bioelectronic devices.

The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts

This study shows that KDM5C, an X-linked demethylase, promotes energy metabolism in osteoclasts to regulate female bone mass, offering a new target for osteoporosis treatment in women.

Adult thymus-derived cMaf+ RORγt+ γδ T cells lack Scart2 chromatin accessibility and do not reach periphery