An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment
J. Srinivasan, A. Vasudev, H. J. Selden, E. Perez, B. J. LaFleur, S. A. Sinari, A. Krueger, E. R. Richie, L. I. R. Ehrlich
The paper shows that early T-cell progenitors decline by 3 months in mice due to reduced pre-thymic progenitors and diminished Notch signaling.
bioRxiv · Jan 18, 2022 · PreprintImmunology