L. I. R. Ehrlich

This study shows CCR4 and CCR7 differentially regulate thymocyte subset localization and central tolerance outcomes through distinct mechanisms and APC interactions.

The paper shows that early T-cell progenitors decline by 3 months in mice due to reduced pre-thymic progenitors and diminished Notch signaling.

This study shows that the middle-aged thymic environment impairs central tolerance by reducing mTECs and antigen-presenting cells, leading to less efficient negative selection and Treg induction.

This study identifies integrin-mediated adhesion and FAK/PYK2 signaling as critical for myeloid cell support of T-ALL, showing their role in survival and progression.