Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation
S. Solier, S. Muller, T. Caneque, A. Versini, L. Baron, P. Gestraud, N. Servant, L. Emam, A. Mansart, G. D. Pantos, V. Gandon, V. Sencio, C. Robin, F. Trottein, A.-L. Begue, , R. Rodriguez
The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.
bioRxiv · Mar 29, 2022 · PreprintCell Biology