Author

N. Servant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. Rodriguez· 3 shared A. Versini· 2 shared F. Sindikubwabo· 2 shared S. Muller· 2 shared T. Caneque· 2 shared A. Deik· 1 shared A. Durand· 1 shared A. E. Cohen· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

R. Rodriguez

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ether lipids influence cancer cell fate by modulating iron uptake

R. P. Mansell, S. Müller, J.-S. Yang, S. Innes-Gold, S. Das, F. Reinhardt, K. J. Sigmund, V. V. Phadnis, Z. Wan, J. Stark, D. Hwang, F. Sindikubwabo, L. Syx, N. Servant, E. N. Eaton, , W. S. Henry

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

bioRxiv · Mar 20, 2024Cancer Biology

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation

S. Solier, S. Muller, T. Caneque, A. Versini, L. Baron, P. Gestraud, N. Servant, L. Emam, A. Mansart, G. D. Pantos, V. Gandon, V. Sencio, C. Robin, F. Trottein, A.-L. Begue, , R. Rodriguez

The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.

bioRxiv · Mar 29, 2022 · PreprintCell Biology

CD44 regulates epigenetic plasticity by mediating iron endocytosis

S. Muller, F. Sindikubwabo, T. Caneque, A. Lafon, A. Versini, B. Lombard, D. Loew, A. Durand, C. Valot, S. Baulade, N. Servant, R. Rodriguez

This study identifies CD44 as a mediator of iron endocytosis linked to epigenetic plasticity, showing iron's role in regulating histone modifications and gene expression during mesenchymal transitions.

bioRxiv · Jul 9, 2019Cell Biology

Lineage tracing of Notch1-expressing cells in intestinal tumours reveals a distinct population of cancer stem cells.

L. Mourao, G. Jacquemin, M. Huyghe, W. J. Nawrocki, N. Menssouri, N. Servant, S. Fre

The paper identifies Notch1-expressing cells in intestinal tumors as a distinct population of cancer stem cells with properties similar to intestinal stem cells but reduced Lgr5 expression.

bioRxiv · Jul 9, 2018Cancer Biology