F. Trottein

Major Metabolites From Hypericum perforatum L., Hyperforin And Hypericin, Are Both Active Against Human Coronaviruses

This study shows that hyperforin from Hypericum perforatum inhibits multiple coronaviruses, including SARS-CoV-2, with antiviral activity confirmed in human cells and potential for combination therapy with remdesivir.

IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections

The paper identifies PD-L1+ neutrophils in severe viral respiratory infections, showing they have regulatory functions and are generated in the bone marrow via IFN-γ.

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation

The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.

A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

This paper identifies clofoctol as an antiviral against SARS-CoV-2, showing it inhibits viral replication and reduces lung pathology in mice.

High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision

The paper uses single-cell transcriptomics to uncover developmental trajectories of iNKT cells and identifies FHL2 as a regulator of iNKT1 fate.