A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR
P. Sievers, M. Sill, D. Schrimpf, D. Stichel, D. E. Reuss, D. Sturm, J. Hench, S. Frank, L. Krskova, A. Vicha, M. Zapotocky, B. Bison, P. N. Harter, M. Snuderl, C. M. Kramm, , F. Sahm
This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.
bioRxiv · Aug 28, 2020Cancer Biology