Cancer BiologybioRxiv
A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR
P. Sievers, M. Sill, D. Schrimpf…·F. Sahm
This study identifies a distinct subset of pediatric gliomas with EGFR alterations, H3K27me3 loss, and broad tumor localization, suggesting EGFR inhibition as a potential therapy.
DOI 10.1093/neuonc/noaa251