A. Villarroel

This study shows that EF3 hand of calmodulin mediates redox regulation of Kv7 channels by translating Ca2+ signals and reversing FRET signals in response to oxidation.

This study uses molecular dynamics simulations to investigate how calmodulin induces a full alpha-helix in the SK2 channel's CaMBD, revealing hydrophobic interactions and the stabilizing role of a pre-folded helix.

The paper develops a gene-specific machine learning model to improve the prediction of KCNQ2 missense variant pathogenicity with high sensitivity and specificity.

The paper shows that the W344R mutation in Kv7.2 channels causes co-translational misfolding, impairing CaM binding and leading to non-functional ion channels.