SARS-CoV-2 3CLpro mutations confer resistance to Paxlovid (nirmatrelvir/ritonavir) in a VSV-based, non-gain-of-function system
E. Heilmann, F. Costacurta, A. Volland, D. von Laer
The paper identifies SARS-CoV-2 3CLpro mutations that confer resistance to Paxlovid using a VSV-based system and finds these mutations already exist in viral sequences.
bioRxiv · Jul 2, 2022 · PreprintMicrobiology