A. W. Avery

Cardiomyopathy-Associated Variants Alter the Structure and Function of the α-Actinin-2 Actin-Binding Domain

This study investigates how cardiomyopathy-associated variants in the α-actinin-2 actin-binding domain affect its structure and function, finding that some variants disrupt actin binding and may contribute to disease.

Increased actin binding is a shared molecular consequence of numerous spinocerebellar ataxia mutations in β-III-spectrin

This study shows that multiple SCA5 mutations increase actin-binding affinity, with some mutations causing earlier symptom onset.

Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia

The paper develops an in vitro FRET assay to identify small molecule modulators of the L253P mutant β-III-spectrin actin-binding domain, identifying potential drug candidates for SCA5 treatment.

Dynein acts to cluster glutamate receptors and traffic the PIP5 kinase, Skittles, to regulate postsynaptic membrane organization at the neuromuscular junction

This study identifies dynein's role in clustering glutamate receptors and trafficking Skittles to regulate postsynaptic membrane organization at neuromuscular junctions.